RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-122
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
KLF6
Pathway
NA
PubMed ID
Title
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
Year
2012
Function
"Mir-122 overexpression reverses liver disease. The incidence of hepatic fibrosis may be attributed in part to the role of the mir-122a target klf6 transcript. In addition, the mir122a -/- Liver is shown to be interrupted in a series of pathways, many of which are very similar to those found in human hcc."